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However, it is unclear whether the peptide has the same anti-inflammatory potential on other dental pulp cell lines (such as fibroblasts and lymphocytes), an in vivo model should be further established to clarify the anti-inflammatory and osteo-/odontoblastic differentiation effect of Pep-B, as well as determine the optimal concentration for in vivo application and improve its stability by modifying the structure or using suitable scaffold materials [64]

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A cohort study of 20 transmasculine patients found that facial and truncal acne increased over 4 months of testosterone treatment, from 35% to 82% and 15% to 88% respectively