Once activated, the typical Wnt pathway induces the stability of -catenin and transfers it to the nucleus, ultimately facilitating the expression of genes involved in cell proliferation, survival, differentiation, and migration (Fig
Amylin receptor components and the leptin receptor are co-expressed in single rat area postrema neurons
Konopleva M, DiNardo C, Bhagat T, Baran N, Lodi A, Saxena K, Cai T, Su X, Skwarska A, Guerra V, Kuruvilla V, Konoplev S, Gordon-Mitchell S, Pradhan K, Aluri S, Collins M, Sweeney S, Busquet J, Rathore A, Deng Q, Green M, Grant S, Demo S, Choudhary G, Sahu S, Agarwal B, Spodek M, Thiruthuvanathan V, Will B, Steidl U, Tippett G, Burger J, Borthakur G, Jabbour E, Pemmaraju N, Kadia T, Kornblau S, Daver N, Naqvi K, Short N, Garcia-Manero G, Tiziani S, Verma A
Formal studies on the combination are still limited, but the non-overlapping mechanisms and clean individual safety profiles make a compelling case