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Interestingly, PHGDH also affects tumor biology independently of its effects in serine metabolism, for example, directly interacting with the RNA-binding protein Poly(rC)-binding protein 2 (PCBP2), and inhibiting its proteasomal degradation
**Reduced Hyperpigmentation:** Glutathione is sometimes used to address hyperpigmentation issues, such as melasma or dark spots
Luthione Glutathione is responsible for various facets of the treatment's success
The upregulated DDX5 then recruits Protein Inhibitor of Activated STAT (PIAS)1, an inhibitory protein of STAT1, thereby blocking STAT1 phosphorylation and activation
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