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Later meta-analyses also report small but significant reductions in body weight, BMI or fat mass, with effects more relevant in overweight or obese populations

Animal blood samples have been recovered according to EU Directive 2010/63/EU for animal experiments

Fourth, an important issue that is often raised is whether any GLP-1RAs can indeed penetrate the bloodbrain barrier and therefore express any neurobiological activity in the CNS, which would result in cognitive or behavioral changes