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Consistent with this, KEGG pathway analysis revealed downregulation of -oxidation in KO mice, accompanied by upregulation of glycolysis and mitochondrial oxidative phosphorylation, reflecting a systemic shift in fuel preference toward carbohydrates driven by carnitine depletion and impaired fatty acid oxidation

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After experimenting on the lizard, Drucker and his team found that these reptiles are very unique in that it has genes for Exendin-4, the protein that became the first diabetes GLP-1 treatment, he explained

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