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And so, GLP-1 therapies improve weight, blood sugar and lipid profiles, and some have demonstrated cardiovascular event reduction in high-risk populations, which makes them particularly relevant for patients with RA who also have diabetes or obesity-related cardiovascular risk

Several preclinical and animal studies have suggested that GLP-1RAs may have neurotrophic and neuroprotective effects, by reducing neuroinflammation, oxidative stress, apoptosis, and mitochondrial dysfunction and by promoting the growth and repair of neural cells, potentially enhancing cognitive functions [73,74,75]