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Overall, the literature suggests that curcumin exerts its beneficial effects through modulation of various signaling pathways, including NF-B, NLRP3, AKAP150/PKA/PP2B, miR-146a-5p/ERK, BDNF/Trkin, ROS-ERK1/2, GABAA receptor, gut-brain axis and Keap1-Nrf2-ARE, in different disease models and conditions

This article summarizes the data on analyses performed in the CSF of patients diagnosed with PD compared with controls, with regard to: (1) concentrations of neurotransmitters (mainly monoamines and their metabolites), neuromodulators, and related substances as possible biological markers of the disease itself or its complications