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On the pancreatic cancer question specifically, a study of over 540,000 adults found no support for an increased pancreatic cancer incidence over 7 years following start of GLP-1RA treatment. The authors note that longer follow up is still needed, however, and its important to consider how the use of these drugs has skyrocketed recently

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DPP-IV activity is upregulated during inflammatory responses, and preclinical models of colitis have demonstrated that DPP-IV inhibitors reduced the expression of proinflammatory cytokines and improved histological outcomes (77)