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[15] Some patients may experience severe nausea and vomiting, which can lead to dehydration, as evidenced by orthostatic hypotension as well as acute renal insufficiency

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While the NIH does not specify a tolerable upper intake level for vitamin B12, a study published in the JAMA Network Open found that high intakes of vitamin B12, such as from daily supplementation of 25 micrograms or higher, increased the risk of bone fracture [3] [4]