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These drugs were chosen because they represent different modes of action: paclitaxel and vincristine are microtubule-targeting agents, cisplatin forms covalent bonds with DNA and by that causes intra-strand and inter-strand cross-links that interfere with DNA replication and transcription, and doxorubicin intercalates into DNA and inhibiting topoisomerase II

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TrkB receptor activation BDNF is synthesized as a precursor protein called proBDNF, which is cleaved by proteases into its mature form

Likewise, several dwarf models, including Ames, Snell and growth hormone receptor knockout (GHRKO) mice, are exceptionally long lived 4,5