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A total of 31 DEGs were obtained in enriched KEGG pathway, PPI analysis of DEGs in gene correlation network and combined analysis of DEMs and DEGs

We also found a significant reduction in the levels of tumor promoter GPs at the end of 4th week during 4-week intermittent fasting (POLK, CD109, CAMP, NIFK, SRGN), and 1 week after 4-week intermittent fasting (CAMP, PLAC1) compared with the levels before 4-week intermittent fasting

Combined with the D+Q associated reduction in ventricle size as assessed by MRI, a surrogate measure of neurodegeneration, the data suggested that clearing senescent cells was beneficial for neuronal preservation

PAK4: P21-activated kinase-4