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Severe reactions (and should be seen immediately in the doctors office or Emergency Department) include seizures, lethargy (and unable to be woken), wheezing, hives, dizziness, swelling of the throat, fainting or rapid heartbeat

In contrast, CGRP has been shown to enhance IL-1, IL-6 and TNF- secretion in a concentration-dependent manner in lymphocyte-enriched mononuclear cells derived from human peripheral blood (121), and have a synergic effect over TNF- secretion when combined with SP (121)

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Naive control rats (unexposed and untreated) underwent identical measurements concurrently with the experimental groups and served as companion controls