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Increased activity of ASM is a hallmark of MDD metabolic alterations, which promotes the breakdown of sphingolipids into ceramides, which in turn induces neuroinflammation (25), leading to neuronal apoptosis and impaired synaptic plasticity

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and the long term effect, to the increased gene expression of tyrosine hydroxylase, probably through a mechanism that involves an increase in intracellular cAMP

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doi: 10.1207/s15327914nc5301_11

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GHK-Cu GHK-Cu for dogs is a copper-binding peptide with strong evidence for wound healing, skin repair, and anti-aging effects

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