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Exclusion criteria for both the FEP and healthy control groups involved meeting criteria for a substance use disorder in the past year according to DSM-5 [36] criteria (this was based on self-report for controls, and in addition clinical assessment and urine drug screening done at the point of clinical assessment in suspected cases for patients), having a history of a major head injury (leading to a significant period of unconsciousness or seizures), having a significant, uncontrolled medical illness, or having any contraindications to undergoing MRI

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Health-related quality of life is significantly impaired across all fibrosis stages, with impairments intensifying with disease severity

They went to a med spa, paid a few hundred dollars for a syringe, and were told to "ramp up the dose every four weeks." A few months in, they were nauseous, fatigued, losing hair, watching the scale move but feeling worse than ever