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As it is known that transactivation of Met can occur via epidermal growth factor (EGF)-dependent EGF receptor (EGFR) activation or through a constitutively activated EGFR pathway 20 , we examined whether inhibition of EGF-induced phosphorylation of EGFR by the dimeric macrocycles caused the bell-shaped response mentioned above

As researchers seek to learn the full extent of its potential, they are optimistic that it could be used to help age-related diseases like cardiovascular disease, mental deterioration, and other illnesses that occur as a result of aging on a cellular level

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