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Diabetes 57:13401348 Shu L, Matveyenko AV, Kerr-Conte J, Cho JH, McIntosh CH, Maedler K (2009) Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell function

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The regulation and maintenance of GSH synthesis is controlled by Nrf2 and by the expression of two types of subunits, the catalytic subunit (Gclc) and the modifier subunit (Gclm), which help in the synthesis of glutamate-cysteine ligase (Gcl) (Moinova and Mulcahy, 1999