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They often make things worse

Yamada Y, Tsukiyama K, Sato T, Shimizu T, Fujita H, Narita T

doi: 10.1016/S0021-9258(18)42253-3 132 FragosoRRenDZhangXSuMWBurakoffSJJinYJ

Fig 3 Differential gene expression revealed a balanced immune response during OPC Differential gene expression analyses (DEG) between OPC and non-infected tissues were carried out using Seurat to identify the most significantly upregulated genes by P -value and L2FC (Log2 fold change) values