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Possible adverse effects in adults: In general adult populations, CoQ10 supplementation can occasionally cause: Gastrointestinal symptoms including nausea, diarrhoea, or stomach upset Headaches or dizziness Insomnia or sleep disturbances (particularly if taken late in the day) Skin rashes or allergic reactions (rare) These effects are typically mild and dose-dependent

The control and experimental groups were divided into cohorts of 8 mice each for natural withdrawal over 7 days, followed by behavioral tests

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Though the normal intestinal microbiome does not include large amounts of pathogenic organisms, as an example, increased proliferation of the pathogen Clostridium botulinum is associated with release of botulinum neurotoxins, damaging the intestinal barrier and fostering absorption of the neurotoxin into the systemic circulation and the nervous system, causing botulism [49]