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Consequently, changes in the leptin-NPY axis may occur in obesity, but paradoxically, the vast majority of obese individuals do not have reduced but higher circulating leptin concentrations that do not lead to a reduction in appetite, indicating leptin resistance (148, 149)

An increase (1.5-2.5 fold) in glutamate-cysteine ligase, aldo keto reductase, thioredoxin reductase, glutathione-S- transferase, and NAD(P)H dehydrogenase quinone1 genes was observed across all treatments (Table 4)

Copper ions naturally accelerate oxidation, and vitamin C is extremely prone to oxidation

In therapy, the new updates include: The decision to keep metformin as the recommended first-line therapy in type 2 diabetes (unlike the European Society of Cardiology)