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The treatment policy estimand evaluated the treatment effect for all randomised subjects regardless of trial product discontinuation and use of rescue medication (data analysed using multiple imputation), whereas the trial product estimand evaluated the treatment effect for all randomised subjects under the assumption that they remained on the trial product for the entire planned duration of the trial and did not use rescue medication (data analysed using a mixed model for repeated measures) [28]

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A typical daily dosage would generally be 1mg per day, 0.25ml or 25 IU on an insulin syringe with 2.5ml of bacteriostatic water

The right dosage, combinations with other therapies, and careful monitoring are critical for success