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Risks factors include age under 24 months (especially those with organic brain disease), developmental delay, coincident congenital metabolic disorders, previous liver dysfunction, or severe epilepsy treated with polytherapy or ketogenic diets [23, 51, 52]

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The findings of an RCT showed that combining pharmacological agents effectively reduced postoperative inflammatory factor expression (IL-1, IL-6, and TNF-) compared with transforaminal endoscopic spinal surgery alone [23]