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Separate vials allow each compound to be prepared, adjusted, tapered or stopped independently

The tested compositions contained semaglutide (0.5 mg/ml), propylene glycol (18.5 mg/ml), disodium hydrogen phosphate dihydrate (1.42 mg/ml), and optionally histidine (10 mM) as specified in Table 1 , at pH 7.4 in an aqueous solution

Abbreviations GLP-1 RAs: Glucagon-like peptide-1 receptor agonists T2DM: Type 2 diabetes mellitus COPD: Chronic obstructive pulmonary disease BMI: Body mass index HbA1c: Glycated hemoglobin RR: Relative risk CI: Confidence interval RCT: Randomized controlled trial CVOT: Cardiovascular outcome trial PRISMA: Preferred reporting items for systematic reviews and meta-analyses References Zar HJ, Ferkol TW