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instead, clinicians reserve it for documented deficiencies or specific clinical indications and follow strict sterile protocols, individualized dosing, and continuous vitalsign monitoring
In PCOS, ovarian tissues and GC is characterized by diminished expression of biogenesis regulatorsPGC-1, nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (TFAM) alongside increased mitochondrial DNA (mtDNA) damage and fragmentation, and ultrastructural abnormalities such as disorganized cristae, swelling, and vacuolization (113)
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Molecular determinants of metabotropic glutamate receptor signaling
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