vitamin-maniac 206 79 3 1070 1.09.2023 , , , , ,
Several studies using animal models and the strategy of GSH depletion by buthionine sulfoximine as an inhibitor of -GCS demonstrated an increase in oxidative stress markers in the liver and various other organs in vivo [22], and the treatment of cells with GSH or N-acetylcysteine limits such damage and renders cells or tissues less susceptible to oxidative stress [23]
It works via the exact same mechanism as a chemical retinoid (so does bidens pilosa), so theyre marketing it as safer because we dont have actual studies that it isnt safe (like we do retinoids) but it makes zero sense that something that works the same way wouldnt also have the same side effects
26, 27, 28 In these studies, the mean concentration of reduced glutathione (GSH), the primary intracellular antioxidant and redox buffer, was found to be significantly decreased, whereas oxidized glutathione disulfide (GSSG) was significantly increased, resulting in a decrease in the glutathione redox ratio (GSH/GSSG) in both plasma and primary immune cells from children with autism
