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Galderma premieres positive interim results demonstrating the efficacy of its Injectable Aesthetics portfolio in addressing facial volume loss as a result of medication-driven weight loss Three-month interim data from first-of-its-kind trial demonstrate that the combination of Sculptra and Restylane Lyft or Contour effectively improved the facial aesthetic appearance of patients experiencing medication-driven weight loss with associated facial volume loss 1 A six-month extension study is ongoing to capture the combined and sustained effects of these treatments over time Galderma is well-positioned to support patients specific needs in this area, given its unique expertise in dermatology, including aesthetics, and its individualized treatment approach developed in close collaboration with healthcare professionals Zug, Switzerland January 14, 2025 Galderma announces positive first results from a trial designed to explore the benefits of Restylane Lyft or Contour in combination with Sculptra in patients with medication-driven weight loss with associated facial volume loss

Treatment typically involves a medical evaluation to determine if it is appropriate, followed by ongoing monitoring to ensure safety and effectiveness

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For instance, the pleckstrin homology domain interacting protein (PHIP) protein acts as a transcriptional co-regulator that directly modulates POMC transcription, whereas the SIM1 transcription factor is indispensable for the normal development of the PVN and the proper expression of MC4R [8,13]