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A position paper by the Autoimmune gastRitis Italian netwOrk Study grOup (ARIOSO)

Advanced techniques like fluorescence in situ hybridization can detect the deletion in the 15q11-q13 parts of the gene, and chromosomal microarray can detect if both copies of the gene are from the mother

Such a mechanism could theoretical be mediated by the oncoprotein MDM2, which interacts with p53 but has recently also been found to associate with certain cell surface receptors and regulate their functions (Shenoy et al, 2001)

Novo Nordisk submitted a New Drug Application to the FDA on December 18, 2025, with FDA review expected during 2026