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For particularly stubborn migraines, especially those lasting more than 72 hours (known as status migrainosus), dihydroergotamine (DHE) can be a game-changer

It has also been found effective in treating chronic fatigue syndrome, a long-term illness characterized by extreme tiredness

When combined with amylin-like signaling from cagrilintide, the overall effect may be stronger appetite suppression than with a single pathway alone

When to seek help Contact your clinic or a doctor if you have severe or escalating pain, swelling that worsens after several days rather than improving, signs of infection (pus, spreading redness, fever), unusual skin discolouration, or lumps that persist beyond three to four weeks