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10 This finding raises the question of whether the activation of p70S6K1 by OSI-906 is through IGF-1R inhibition or it is a non-specific effect of OSI-906

Nasal spray: 500 mcg/0.1 mL (per actuation), packaged in a single-use device containing 0.125 mL of solution Cyanocobalamin Nasal Spray is contraindicated in patients with hypersensitivity to cobalt and/or vitamin B12 or any of its excipients [see Warnings and Precautions (5.2)]