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Some experts have cautioned against their use, pointing to concerns over incorrect dosing, potential contaminants, unintended biological effects and the lack of human testing

We note that REHs are statutorily required to have in effect a transfer agreement with a level I or level II trauma center, such that patients that present at an REH with needs for longer-term inpatient care may receive that care

Neuropathological investigations in the substantia nigra pars compacta of Parkinsons disease patients demonstrate that deficient PGC-1 expression compromises mitochondrial biogenesis and disrupts the coordinated transcriptional activation of antioxidant stress-responsive gene networks, thereby precipitating dopaminergic neuronal degeneration (Piccinin et al., 2021)