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Biased agonism is a term used to describe ligand-mediated activation of a specific subset of the intracellular signaling pathways linked to a single receptor 47

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The number of glaucoma cases associated with an actually elevated IOP varies significantly across glaucoma subtypes, and many glaucoma patients progress to blindness despite low IOPs and/or are refractory to IOP-lowering treatments (Heijl et al., 2002