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Nrf2 Activation: In response to oxidative stress, Nrf2 activates the transcription of genes involved in antioxidant defense, including those involved in the synthesis of glutathione

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10.1016/j.lfs.2005.05.103

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DT induced ferroptosis and apoptosis of breast and lung cancer cells by repressing GPX4 expression, thus significantly inhibiting tumor growth without adverse effects in a xenograft nude mouse model (Lin et al., 2019

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