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Experimental models of cardiomyopathy have been corrected with the administration of L-carnitine, and primary carnitine deficiency has been associated with left ventricular hypertrophy in animal models
In addition, it interferes with the activation of activated T-cell nuclear factor 1 (NFATC1), a key transcription factor for activated T-cell function, which is linked to ATP deficiency
10.1136/bmjopen-2016-013739 41 KolbH.MartinS.KempfK
Baseline disease severity varied, with some trials including patients beyond the therapeutic window in which hepatic regeneration strategies could plausibly affect outcomes
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