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It was first approved for the treatment of type 2 diabetes as a once-weekly injection (0.5 mg, 1 mg, or 2 mg) in 2017 (Ozempic) and as a once-daily oral pill (7 mg or 14 mg) in 2019 (Rybelsus)

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doi: 10.3238/arztebl.2011.0795

Retatrutide May Be Preferred For Patients with severe obesity requiring maximum weight loss MASH / fatty liver disease where liver fat reduction is a treatment goal Cases where energy expenditure enhancement could provide additional benefit Patients who have plateaued on dual-agonist therapy Tirzepatide May Be Preferred For Type 2 diabetes with weight management (approved indication) Patients who prioritize an established safety profile Cardiovascular risk populations (pending SURPASS-CVOT data) Settings requiring an FDA-approved, commercially available option The Bottom Line Comparing retatrutide and tirzepatide today is comparing a promising research compound against a proven pharmaceutical