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Conclusions SIBO is a central gastrointestinal complication of SSc, arising from fibrosis, dysmotility, vascular injury, and immune dysregulation

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The microchannel window: 4 to 6 hours of enhanced penetration The microchannels created by SkinPen microneedling remain functionally open for approximately 4 to 6 hours after treatment

Questions still remain The FDA meeting is unlikely to settle the broader debate around peptides