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The innate immune system plays a dominant role, with self-antibodies (such as anti-CD74 and anti-cyclic citrullinated peptide) as well as T cell activation and clonal expansion supporting its autoimmune components, and both autoinflammatory and autoimmune factors may continuously participate in its pathogenesis (199202)

Growth hormone-releasing peptide 2 (GHRP-2) has shown reduced M1 macrophage polarization at the tendon-bone interface in rat models, potentially improving the healing environment after surgical repair

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