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However, data to the contrary also exist and some small studies raised concerns that GLP1-RA use in CKD may be associated with more gastrointestinal side effects, hypoglycemic events, and loss of muscle mass 17,18

Treatment with proton pump inhibitors (PPIs) or H2 blockers can address the acid component, often reducing burping as a secondary benefit

, The trial protocol and statistical analysis plan are in the Supplement

For related setmelanotide indications (Bardet-Biedl syndrome), Canadian health technology assessments published in 2023 estimated annual costs of approximately $294,000 per year for pediatric patients and $441,000 per year for adults at full dose