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Through targeted metabolomics analysis, Yuan et al

As body composition changesparticularly with loss of adipose tissuethermoregulation is affected because fat serves primarily as insulation, while heat generation comes largely from metabolically active lean tissue

While the use of Semaglutide in bodybuilding is still in its infancy and off-label, ongoing research efforts and clinical investigations may shed light on its efficacy, safety, and clinical applications in athletic populations