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Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-kappaB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IkappaBalpha kinase activation

This fungus is consistently enriched in various CLDs (including ALD, MASLD, cirrhosis, and HCC) and is associated with disease severity and poor prognosis, suggesting that targeting this single pathogen could have broad therapeutic effects

doi: 10.1093/ejendo/lvac006 299 MerkeDPMallappaAArltWBrac de la PerriereALindn HirschbergAJuulAet al

The use of compounds that stimulate Sirtuin and AMPK modulators SIRT1/SIRT6 (e.g., resveratrol, NMN) has shown potential to restore mitochondrial biogenesis and attenuate OS in insulin-resistant tissues (Wang et al., 2023), although robust clinical trials are lacking