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It has been well established that Abeta, when incubated with copper and oxygen, produces H 2 O 2 , while reducing Cu 2+ to Cu 1+ , during the period when it slowly transforms into soluble oligomers ( 2 O 2 , levels decrease, suggesting that the fibrils that are ultimately formed may clear the H 2 O 2

Determining the extent to which GLP-1 RAs modulate neuroaffective responses to food-related cues and other motivationally relevant stimuli is critical both for understanding their mechanisms of action and for assessing their promise as treatments for maladaptive reward-seeking behaviors, including substance use disorders

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