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Al-Hadrawi DS, Al-Rubaye HT, Almulla AF, Al-Hakeim HK, Maes MF

ACE2 in brain physiology and pathophysiology: evidence from transgenic animal models

Furthermore, to prevent irritation and maintain microbial defense, the pH of the nasal formulation should be adjusted slightly acidic, as lysozymes in nasal secretions effectively destroy bacteria at acidic pH but become inactivated under alkaline conditions, leaving tissue vulnerable to infection [101]