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Involvement of the gut microbiota in IR Influencing factors of Gut microbiome composition The microbes living in the human gut are key contributors to host metabolism and immune function through mediating the interaction between the host and environment, or releasing metabolites and cytokines

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Pregnancy and breastfeeding Berberine should be avoided during pregnancy due to potential harm to the foetus and should not be used whilst breastfeeding due to insufficient safety data

Increased Satiety and Fullness Semalutides peripheral appetite suppression also comprises agonism of the GLP-1 receptors present in the GI tract