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The mechanism by which GLP-1 receptor agonists might contribute to pancreatitis risk remains unclear, but possibilities include effects on pancreatic enzyme secretion, changes in gallbladder motility leading to gallstone formation, or direct effects on pancreatic tissue

For this reason, it was thought that the enzyme played an important role in ammonia detoxification, because since high [NH 4 + ] are toxic, this equilibrium position would be physiologically important

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1 The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) estimates that more than 1 in 3 U.S