heartburn with tirzepatide and Acid Reflux: Managing GI Side Effects 18 Possible Side Effects of

doi:10.1172/JCI28773

Second, contrary to CVOTs on GLP-1 RAs that included T2DM patients with established cardiovascular disease or at high cardiovascular risk, tirzepatide trials randomized T2DM patients irrespective of presence of prior cardiovascular disease or cardiovascular risk factors, a fact that may account for the very low number of recorded MACE, and possibly for type II errors

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