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Initially approved for type 2 diabetes (T2D) treatment, they were later found to influence appetite regulation (145, 146) by regulating activity in hedonic brain regions like the insula and orbitofrontal cortex changing food preference (147), therefore, leading to their approval for obesity and diabetes management (148150)

Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3Bnull mice

doi: 10.1016/j.cell.2016.01.013 89 KnezMRanicMStangoulisJCRGlibeticM

For definitions of terms used here (lyophilization, bacteriostatic water, glycosaminoglycan, and others), the peptide glossary is a useful companion