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Quantitative RT-polymerase chain reaction analysis According to the manufacturers instructions, total RNA was isolated from mouse dorsal skin using RNAiso Plus, and the extracted RNA was quantitatively analyzed by spectrophotometry

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From a clinical safety perspective, individuals with a history of pancreatitis or gallbladder disease should ensure their trial clinician is aware of this, as these conditions are relevant to the risk profile of GLP-1 receptor agonist class medicines