A meta-analysis showed that GLP-1RA may be superior to metformin in improving insulin sensitivity in PCOS patients.29 In terms of improving reproductive function, studies have shown that GLP-1RA can reduce total testosterone (T) and free T levels in obese PCOS patients, thereby alleviating hyperandrogenism, improving menstruation, and increasing fertility rates.30,31 Recent studies have shown that GLP-1 can reduce ferredoxin 1 levels in the ovaries of PCOS rats.32 Hirsch et al found that treatment with liraglutide resulted in weight loss, menstrual cycle restoration, and improved hyperandrogenism in PCOS.33 Metformin combined with exenatide can reduce weight, BMI, and waist circumference and improve insulin sensitivity in women with PCOS.34 Thus, the role of GLP-1RA in PCOS mainly focuses on improving body weight and IR
Clinical trials showed that recipients using weekly doses experienced a mean weight loss of up to 20% at 72 weeks
In addition, GLP-1R agonists have been observed to enhance the health of endothelial cells in the brain, promoting vascular remodeling, which may further support cognitive function
Because pricing can change, the best approach is to contact the clinic directly for current information
