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Toxicokinetic modeling A population toxicokinetic analysis was performed using a nonlinear mixed-effects model

The highest concentration of glutathione is found in the liver, where it offers antioxidant support for liver tissue protection and p450 phase II conjugation pathways, a possible source of reactive oxygen species

In the study of Tagitinin C-induced ferroptosis in colorectal cancer cells, it was found that the mechanism of action of Tagitinin C might be related to the activation of the PERK-Nrf2-HO-1 signaling pathway induced by ER stress, leading to ferroptosis (84)