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Specific situations warrant urgent professional dietary consultation: Unintentional excessive weight loss losing more than 1 kg weekly consistently, or experiencing rapid weight loss that feels uncontrolled Inability to meet minimum calorie requirements due to severe appetite suppression, nausea, or other side effects Signs of nutritional deficiency , including unusual fatigue, weakness, hair loss, brittle nails, frequent infections, or poor wound healing Pre-existing eating disorders or disordered eating patterns, as GLP-1 medications may complicate these conditions Complex medical conditions such as chronic kidney disease, liver disease, or malabsorption disorders requiring specialised dietary management Pregnancy or breastfeeding GLP-1 medications should not be used during pregnancy

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Mechanistic details of glutathione biosynthesis revealed by crystal structures of Saccharomyces cerevisiae glutamate-cysteine ligase