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[5] [11] Poor diabetes control from ineffective medication can lead to: Persistent hyperglycaemia with symptoms including increased thirst, frequent urination, and fatigue Elevated HbA1c levels, increasing the risk of microvascular complications (retinopathy, nephropathy, neuropathy) [16] [17] Greater likelihood of macrovascular complications (cardiovascular disease, stroke) Risk of hyperosmolar hyperglycaemic state (HHS) in some individuals with type 2 diabetes [20] [21] Additional concerns include the theoretical risk of increased impurities or degradation products, although there is no official link between expired Trulicity and specific toxic effects

This additional mechanism is particularly relevant for women with PCOS

Further improvements were made by the company in order to increase the daily dose of methionine, while limiting -carotene to the shell, because of cosmetic distress from a yellow hue, resulting in Antox version 1.2

Excipients: Some excipients can influence the rate of drug release from the injection site