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The PH domain of 2 and 3 plays a dual role, much like PLC-1, by binding to the plasma membrane, as well as being a site of interaction for the catalytic activator

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Mechanisms of Action Once ingested, L-theanine readily crosses the bloodbrain barrier, where it influences several neurotransmitter systems: Glutamate modulation : L-theanine interacts with glutamate receptors, dampening excessive excitatory signalling that can contribute to stress and mental overactivity

American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee